Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?
Identifieur interne : 001905 ( Main/Exploration ); précédent : 001904; suivant : 001906Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?
Auteurs : Erich Hoffmann ; Juergen Stech ; Irina Leneva ; Scott Krauss ; Christoph Scholtissek ; Po San Chin ; Malik Peiris ; Kennedy F. Shortridge ; Robert G. WebsterSource :
- Journal of Virology [ 0022-538X ] ; 2000.
Abstract
In 1997, an H5N1 influenza virus outbreak occurred in chickens in Hong Kong, and the virus was transmitted directly to humans. Because there is limited information about the avian influenza virus reservoir in that region, we genetically characterized virus strains isolated in Hong Kong during the 1997 outbreak. We sequenced the gene segments of a heterogeneous group of viruses of seven different serotypes (H3N8, H4N8, H6N1, H6N9, H11N1, H11N9, and H11N8) isolated from various bird species. The phylogenetic relationships divided these viruses into several subgroups. An H6N1 virus isolated from teal (A/teal/Hong Kong/W312/97 [H6N1]) showed very high (>98%) nucleotide homology to the human influenza virus A/Hong Kong/156/97 (H5N1) in the six internal genes. The N1 neuraminidase sequence showed 97% nucleotide homology to that of the human H5N1 virus, and the N1 protein of both viruses had the same 19-amino-acid deletion in the stalk region. The deduced hemagglutinin amino acid sequence of the H6N1 virus was most similar to that of A/shearwater/Australia/1/72 (H6N5). The H6N1 virus is the first known isolate with seven H5N1-like segments and may have been the donor of the neuraminidase and the internal genes of the H5N1 viruses. The high homology between the internal genes of H9N2, H6N1, and the H5N1 isolates indicates that these subtypes are able to exchange their internal genes and are therefore a potential source of new pathogenic influenza virus strains. Our analysis suggests that surveillance for influenza A viruses should be conducted for wild aquatic birds as well as for poultry, pigs, and humans and that H6 isolates should be further characterized.
Url:
PubMed: 10864640
PubMed Central: 112136
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000136
- to stream Pmc, to step Curation: 000136
- to stream Pmc, to step Checkpoint: 000C76
- to stream Ncbi, to step Merge: 000020
- to stream Ncbi, to step Curation: 000020
- to stream Ncbi, to step Checkpoint: 000020
- to stream Main, to step Merge: 001948
- to stream Main, to step Curation: 001905
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?</title>
<author><name sortKey="Hoffmann, Erich" sort="Hoffmann, Erich" uniqKey="Hoffmann E" first="Erich" last="Hoffmann">Erich Hoffmann</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stech, Juergen" sort="Stech, Juergen" uniqKey="Stech J" first="Juergen" last="Stech">Juergen Stech</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leneva, Irina" sort="Leneva, Irina" uniqKey="Leneva I" first="Irina" last="Leneva">Irina Leneva</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chin, Po San" sort="Chin, Po San" uniqKey="Chin P" first="Po San" last="Chin">Po San Chin</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shortridge, Kennedy F" sort="Shortridge, Kennedy F" uniqKey="Shortridge K" first="Kennedy F." last="Shortridge">Kennedy F. Shortridge</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">10864640</idno>
<idno type="pmc">112136</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC112136</idno>
<idno type="RBID">PMC:112136</idno>
<date when="2000">2000</date>
<idno type="wicri:Area/Pmc/Corpus">000136</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000136</idno>
<idno type="wicri:Area/Pmc/Curation">000136</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000136</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C76</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C76</idno>
<idno type="wicri:Area/Ncbi/Merge">000020</idno>
<idno type="wicri:Area/Ncbi/Curation">000020</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000020</idno>
<idno type="wicri:doubleKey">0022-538X:2000:Hoffmann E:characterization:of:the</idno>
<idno type="wicri:Area/Main/Merge">001948</idno>
<idno type="wicri:Area/Main/Curation">001905</idno>
<idno type="wicri:Area/Main/Exploration">001905</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?</title>
<author><name sortKey="Hoffmann, Erich" sort="Hoffmann, Erich" uniqKey="Hoffmann E" first="Erich" last="Hoffmann">Erich Hoffmann</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stech, Juergen" sort="Stech, Juergen" uniqKey="Stech J" first="Juergen" last="Stech">Juergen Stech</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leneva, Irina" sort="Leneva, Irina" uniqKey="Leneva I" first="Irina" last="Leneva">Irina Leneva</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chin, Po San" sort="Chin, Po San" uniqKey="Chin P" first="Po San" last="Chin">Po San Chin</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shortridge, Kennedy F" sort="Shortridge, Kennedy F" uniqKey="Shortridge K" first="Kennedy F." last="Shortridge">Kennedy F. Shortridge</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
<affiliation><nlm:aff id="N0x9c59020.0x9f0ea28"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>In 1997, an H5N1 influenza virus outbreak occurred in chickens in Hong Kong, and the virus was transmitted directly to humans. Because there is limited information about the avian influenza virus reservoir in that region, we genetically characterized virus strains isolated in Hong Kong during the 1997 outbreak. We sequenced the gene segments of a heterogeneous group of viruses of seven different serotypes (H3N8, H4N8, H6N1, H6N9, H11N1, H11N9, and H11N8) isolated from various bird species. The phylogenetic relationships divided these viruses into several subgroups. An H6N1 virus isolated from teal (A/teal/Hong Kong/W312/97 [H6N1]) showed very high (>98%) nucleotide homology to the human influenza virus A/Hong Kong/156/97 (H5N1) in the six internal genes. The N1 neuraminidase sequence showed 97% nucleotide homology to that of the human H5N1 virus, and the N1 protein of both viruses had the same 19-amino-acid deletion in the stalk region. The deduced hemagglutinin amino acid sequence of the H6N1 virus was most similar to that of A/shearwater/Australia/1/72 (H6N5). The H6N1 virus is the first known isolate with seven H5N1-like segments and may have been the donor of the neuraminidase and the internal genes of the H5N1 viruses. The high homology between the internal genes of H9N2, H6N1, and the H5N1 isolates indicates that these subtypes are able to exchange their internal genes and are therefore a potential source of new pathogenic influenza virus strains. Our analysis suggests that surveillance for influenza A viruses should be conducted for wild aquatic birds as well as for poultry, pigs, and humans and that H6 isolates should be further characterized.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Chin, Po San" sort="Chin, Po San" uniqKey="Chin P" first="Po San" last="Chin">Po San Chin</name>
<name sortKey="Hoffmann, Erich" sort="Hoffmann, Erich" uniqKey="Hoffmann E" first="Erich" last="Hoffmann">Erich Hoffmann</name>
<name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name>
<name sortKey="Leneva, Irina" sort="Leneva, Irina" uniqKey="Leneva I" first="Irina" last="Leneva">Irina Leneva</name>
<name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
<name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name>
<name sortKey="Shortridge, Kennedy F" sort="Shortridge, Kennedy F" uniqKey="Shortridge K" first="Kennedy F." last="Shortridge">Kennedy F. Shortridge</name>
<name sortKey="Stech, Juergen" sort="Stech, Juergen" uniqKey="Stech J" first="Juergen" last="Stech">Juergen Stech</name>
<name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001905 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001905 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:112136 |texte= Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1? }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:10864640" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |